They say that blood is thicker than water. Is it? Amara and Ava are fraternal twins born under the Blue Crescent moon—a phenomenon that occurs once every fifty years when a new male ruler from any of the supernatural beings is born to rule the world of vampires, werewolves, witches, and humans. Ambrosia, their mother gives birth to them in secret for fear of being killed by Gorgon, the vampire ruler who plots to kill all unborn children before the blue moon ascends. However, Ambrosia had no idea that she has given birth to two daughters. Ava is invisible while Amara is a wolf less crossbreed. The fate separates the twins at birth as they are prophesied to destroy the world when the sisters become one. In order to save her daughter from the blood-thirsty creatures, Ambrosia sends her to the farthest future. In the present day, the teenage twins finally meet as Macy Peterson and Madison Greene without knowing their bond, and all hell breaks loose. Would their union bring peace to both worlds or a much eviler bloodshed?